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数字化定制的推磨牙矫治器及其制作方法

Resumen de: CN121910496A

本发明提供了一种数字化定制的推磨牙矫治器及其制作方法，涉及医疗器械领域。该方法包括：获取患者口腔三维数据建立数字牙列模型；基于模型设计包括定制式带环和横腭杆的一体式结构，并在横腭杆上设计微种植钉孔；采用增材制造工艺制作该一体式结构；最后将一体式结构与一螺旋扩弓器连接。本申请提供的矫治器包括：与磨牙固定的定制式带环、横跨上腭的横腭杆、以及设置在横腭杆上用于植入微种植钉的微种植钉孔，其中带环与横腭杆为一体式结构，并与一螺旋扩弓器连接。本申请解决了现有推磨牙矫治器磨牙远中移动效率不高、支抗不足、舒适度差及个性化精度低的问题，通过数字化流程和骨性支抗，实现了高效精确的矫治，同时提升了佩戴舒适度。

具有取向排列的胶原蛋白基水凝胶、制备方法及其用途

Resumen de: CN121910946A

本申请提供了一种具有取向排列的生物材料基水凝胶及其制备方法，所述生物材料基水凝胶通过包含下述步骤的方法制备得到：将修饰的生物材料溶于培养基中，并加入交联剂和引发剂得到混合物；将混合物进行3D打印，并进行交联得到所述生物材料基水凝胶，其中3D打印的喷嘴直径为200‑350μm，所述的生物材料基水凝胶具有优异的取向排列，用于损伤修复场景时无二次损伤，高水合条件匹配体内组织的理化特性，所述的方法支持一体化成型，无需支撑浴、助剂或纤维加入，且成胶可在1min之内完成，具有高细胞活性；无需额外准备纤维或支持浴，溶解迅速，便于多场景使用，并且实现载多细胞打印构建取向性组织，操作简便，可满足多动物类型、不同尺寸移植需求。

一种氧化锆陶瓷牙周夹板的制备方法

Resumen de: CN121913779A

本发明提供一种氧化锆陶瓷牙周夹板的制备方法，包括以下步骤：制备具有氧化锆粉与醚类有机溶剂的陶瓷浆料；根据患者口内扫描数据，设计贴合患者牙齿舌侧形态的牙周夹板三维数字模型；将陶瓷浆料置入喷墨3D打印设备，将陶瓷浆料与支撑材料同步喷射，逐层打印出牙周夹板的生胚，并在逐层打印过程中，于牙周夹板内部生成若干微腔；对生胚进行高温烧结，得到氧化锆陶瓷牙周夹板成品，将微胶囊分散于溶剂中，通过真空浸渍使微胶囊溶液渗入微腔内部，然后干燥去除溶剂，以使微胶囊置入微腔中；本发明提高牙周夹板的生物相容性，适配不同患者的具体牙周轮廓，固定松动牙，保持牙列固定，并可实现抗菌剂的持续稳定释放，预防牙周感染。

一种个性化根型种植体

Resumen de: CN224155791U

本实用新型公开了一种个性化根型种植体；包括种植本体，所述种植本体的上端开设有中央螺丝孔，所述中央螺丝孔的上部开设有莫氏锥度孔，所述莫氏锥度孔的上端开设有内六角基座孔；本实用新型采用Ti‑Ta合金的种植体，接近人体骨组织，有效降低应力屏蔽效应；同时，钽元素的引入提高了材料的耐腐蚀性和骨结合能力；采用3D打印技术实现种植体完全匹配拔牙窝形态，骨内部分表面构建仿生骨小梁多孔结构的骨孔和凸块，使得种植体便于在牙窝中进行安装；并且在种植体上端设计中央螺丝孔和莫氏锥度孔，便于对假牙进行安装连接，以及在上端设有内六角基座孔，便于提高假牙的连接稳定性，防止假牙旋转脱落。

MOTORIZED STRUT MOTOR FEEDBACK

Resumen de: US20260108275A1

A spatial frame apparatus for positioning on a patient to treat an injury. The apparatus includes a frame having one or more motorized struts. One or more motorized struts include one or more motors configured to cause movement of one or more motorized struts in one or more directions in accordance with one or more treatment plans. The apparatus includes one or more processing 2024/102351 components communicatively coupled to one or more motorized struts and/or one or more motors. One or more processing components determine one or more loading parameters on the one or more motorized struts. The loading parameters define loading on the one or more motorized struts resulting from the frame being positioned and/or adjusted on the patient. The processing components execute at least one adjustment of one or more motorized struts based on the determined loading parameters.

A system and method for evaluating the level of harassment of insects on a plurality of animals

Resumen de: AU2026202539A1

A SYSTEM AND METHOD FOR EVALUATING THE LEVEL OF HARASSMENT OF INSECTS ON A PLURALITY OF ANIMALS The presently disclosed subject matter aims to a system and method for evaluating the level of harassment of flying insects on a plurality of animals located at a given area, 5 the system comprising a processing circuitry configured to: obtain one or more ear movement patterns associated with at least one ear of at least one animal of the plurality of animals, each ear movement pattern is associated with respective ear movement characteristics; for at least part of the one or more ear movement patterns, determine whether their respective ear movement characteristics meet a predefined rule; and, 10 determine whether a number of ear movement patterns whose ear movement characteristics met the predefined rule meets an action requirement rule. A SYSTEM AND METHOD FOR EVALUATING THE LEVEL OF pr p r

NERVE CONDUIT

Resumen de: US20260108247A1

0000 A nerve conduit for supporting repair of a nerve lesion and motor control and/or reducing risk of the development of a neuroma at the lesioned nerve end. The nerve conduit includes an elongate body formed by a wall and including a central portion defining an inner cavity and end portions defining a respective opening to the inner cavity and arranged adjacent to the central portion and at longitudinally opposing ends of the elongate body. One end portion is configured as an insertion portion configured for inserting a respective nerve end. The other end portion is configured as a nerve end outlet portion, an outer diameter of the wall defining the outlet portion is larger than an outer diameter of the wall defining the central portion.

BIOPRINTING ROBOTIC SYSTEM, DEVICE, AND METHOD

Resumen de: US20260108314A1

A bioprinting robotic system comprises a robotic manipulator, a bioprinting instrument configured as an end effector of the robotic manipulator further configured to print bioink, a head mounted display (HMD), an optical tracking system, and a computing system communicatively connected to the robotic manipulator, bioprinting instrument, HMD and optical tracking system. A bioprinting instrument comprises a housing, a distance measurement sensor, a light source, 3D point cloud camera, and a co-axial nozzle positioned on a one degree of freedom (DoF) linear height control mechanism. A bioprinting method comprises providing the bioprinting robotic system above, obtaining a high-resolution volumetric geometry of an injury via the 3D point cloud camera, designing a desired 3D printing geometry and corresponding printing trajectories, calibrating and registering the bioprinting robotic system, displaying on the HMD the desired printing trajectory, and printing along the desired printing trajectory via a surgeon manipulating the bioprinting instrument.

INFUSION VOLUME DETECTION SYSTEM AND METHOD

Resumen de: US20260108673A1

A vision-enabled fluid flow rate detection system is disclosed. The system includes an image sensing device that images an infusion container supplying a fluid to an infusion pump and a pattern of markings associated with a surface of the container, and identifies a visual difference in the pattern from a default state of the pattern to determine a volume of fluid infused from the infusion container, and used to calculate a volume of fluid in the container and a flow rate of the fluid. When the amount of fluid, as determined by the vision system, differs from the amount reported by the pump, the pump's motor may be adjusted to correct the expected volume or flow rate, as needed. When a severe infusion inaccuracy is detected, an alarm or other indication may be provided, or the infusion terminated.

SYSTEMS AND METHODS TO MEASURE, PREDICT AND OPTIMIZE BRAIN FUNCTION

Resumen de: US20260112487A1

Methods and apparatus for changing a brain state of a person from an initial brain state to a target brain state are described. The method includes receiving information characterizing the initial brain state, the information including a structural composition and a functional architecture of the brain, estimating based, at least in part, on the received information, a potential for the brain to change from the initial brain state to the target brain state, determining based, at least in part, on the received information and the estimated potential for the brain to change from the initial brain state to the target brain state, a non-invasive brain stimulation protocol, and controlling at least one non-invasive brain stimulation device to stimulate the brain according to the non-invasive brain stimulation protocol. The method also includes using brain information to inform the design of computational general artificial intelligence agents.

APPARATUSES, SYSTEMS, AND METHODS FOR BIOMARKER COLLECTION, BI-DIRECTIONAL PATIENT COMMUNICATION AND LONGITUDINAL PATIENT FOLLOW-UP

Resumen de: AU2026202565A1

Approaches for generating a set of biomarkers and generating a summary and one or more recommendations based, at least in part, upon the biomarkers are provided. Sensor data associated with a user may be received. The sensor data may be analyzed to generate a set of biomarkers. One or more biomarkers of the set may be combined to generate one or more additional biomarkers. A summary and one or more recommendations may be generated based, at least in part, upon the generated set of biomarkers and the additional biomarkers. The generated summary and the one or more recommendations may be provided for display on a client device. on a client device. pr p r

METHOD AND ANALYSIS SYSTEM FOR CREATING A DIGITAL 3D MODEL OF THE DENTITION OF A PATIENT

Resumen de: US20260108329A1

A method for creating a digital 3D model of a patient's dentition, according to the invention, provides that in a computing unit for a plurality of dentition variants, each comprising a combination of a digital 3D model of the upper jaw and a digital 3D model of the lower jaw of the patient, which differ from each other in the relative positioning of the upper and lower jaws, respectively: the digital 3D model of the upper jaw is combined with the digital 3D model of the patient's lower jaw in such a way that the upper and lower jaws rest on each other at a number of contact points without any spatial overlap of parts of the upper and lower jaws, andthe contact surface between the upper and lower jaw is determined, whereby an optimized denture variant is selected as a 3D model of the denture, taking into account the contact surface.

3D PRINTING INK COMPOSITION AND 3D PRINTING MOLDED ARTICLE FORMED BY CURING SAME

Resumen de: WO2026084480A1

The present disclosure relates to: a 3D printing ink composition comprising alginate, a biocompatible hydrogel, acrylamide-based monomers, a photocrosslinkable polymer, a light absorber, and a solvent; and a 3D printing molded article formed by curing the composition.

3D PRINTED OR OTHER ANATOMICAL AND CIRCULAR GINGIVAL HEALING CUFFS FOR USE WITH ABUTMENTS

Resumen de: US20260108327A1

An assembly comprising an abutment and gingival healing cuff. The gingival healing cuff fits and mates over the abutment, wherein the cuff includes internal surfaces (e.g., at least one flat face, and at least one curved face) corresponding to the external surfaces of the abutment, so as to mate with one another. The gingival healing cuff can further include a rectangular box or other timing alignment structure positioned apical to a buccal alignment body, which serves as a buccal alignment marker once the buccal alignment body is removed, and which can aid in helping the practitioner know where the implant platform and abutment platform are located (even when hidden). Flowable composite, e.g., of a different color, can be placed into the rectangular box or other timing alignment structure to aid in identification of the buccal surface of the cuff and proper rotational alignment (“timing”) of the abutment with the implant.

COMPOSITIONS AND METHODS FOR BIOPRINTING OF ENERGY-RESPONSIVE BIOINKS

Resumen de: WO2026085159A1

Disclosed are methods and compositions to enable bioprinting of energy-responsive bioinks. The embodiments of the present disclosure relate to ultrasound-controlled gene delivery to a target cell in a three-dimensional bioprinted cell construct. The compositions include, for example, a hydrogel scaffold with a plurality of filament structures printed on a substrate; and a collagen cast gel that encases the hydrogel scaffold; wherein the compositions are configured to receive a population of microparticle-coupled cargo for controlled delivery to one or more target cells by application of ultrasound energy. Also disclosed are methods of creating transgenic target cells using the disclosed compositions.

METHOD FOR PRODUCING A TEMPLATE FOR A BONE PLATE

Resumen de: WO2026080955A1

The invention relates to a method for producing a template for a bone plate for treating a fracture of a bone of a human or animal, in particular for a bone plate for treating a pelvic fracture of a human. According to the invention, in order to produce the template in a patient-specific manner with high practical applicability, a digital data set of an image of bone fragments of the fracture is obtained using an imaging method, in particular an MRI or CT or X-ray method, wherein the method comprises the following steps: a) creating a digital, in particular virtual, three-dimensional bone model of the bone fracture fragments on the basis of the data set; b) determining a digital template design adapted to the bone model; c) producing, in particular 3D printing, the template on the basis of the determined template design. The invention also relates to a data processing device, to a system for producing the template, and to a computer program product.

IMAGE-BASED TOOTH IDENTIFICATION USING DIGITAL DENTAL MODELS

Resumen de: US20260108326A1

Systems and methods for identifying teeth in a patient image are provided. For example, a computer-implemented method can include, by one or more processors, accessing a 2D image including a depiction of a patient's teeth, where a plurality of the depicted patient's teeth are annotated with tooth identifiers according to a first tooth identification scheme. The computer-implemented method can further include transmitting, to a server computing device, the 2D image, and receiving from the server computing device, a second tooth identification scheme for the patient's teeth in the 2D image. The second tooth identification scheme can be generated by accessing a 3D model of the patient's teeth, projecting the 3D model onto the 2D image, comparing the projection to the 2D image to determine a probability parameter for each of one or more teeth in the 2D image, and determining, based on the probability parameters, the second tooth identification scheme.

METHOD, DEVICE, AND COMPUTER PROGRAM FOR PREDICTING PROGNOSIS OF INTRAVITREAL INJECTION THERAPY

Resumen de: US20260108215A1

0000 The present invention relates to a method for predicting the prognosis of intravitreal injection treatment, comprising the steps of: receiving OCT images and clinical information of a plurality of diabetic macular edema patients; extracting one or more major lesion information from the OCT images; training a multi-modal deep learning model by inputting the OCT images, the clinical information, and the one or more major lesion features, and outputting the intravitreal injection treatment prognosis of the diabetic macular edema patients; and predicting the prognosis of intravitreal injection treatment by inputting the OCT images, the clinical information, and the major lesion features of a specific diabetic macular edema patient to the trained multi-modal deep learning model.

Advanced Respiratory Monitor and System

Resumen de: US20260108172A1

0000 Disclosed is a bioimpedance measurement system: A stabilized high frequency current generator is connected to padset electrodes via a patient cable. Electrodes are connected to an adaptive circuit that conditions the resulting voltage signal and converts it to digital form. Firmware performs signal acquisition and relays data to the device.

IMPLANT PLANNING SOFTWARE

Resumen de: US20260108304A1

A modified digital library and an algorithm able to make six functions for the improvement of most implant planning software used for the design of the custom surgical guide are provided. The prior art implant planning software available on the market, improved by the modified digital library and algorithm presented here, is essential to guide the digital design of both the custom surgical guide and the CAD-CAM cemented prosthesis onto straight or angled prefabricated abutments, through preliminary determination of abutment position with respect to an appropriate system of reference planes in correspondence with digital crown design. Furthermore, in a future perspective, the improved implant planning software presented here could be usefully employed in robot-assisted dental implant surgery.

LATERAL FLOW ASSAY WITH ENCRYPTED DIAGNOSTIC RESULTS

Resumen de: WO2026083104A1

This invention relates to a method of manufacturing a membrane for lateral flow assay or rapid diagnostic assay, a device comprising a membrane for detecting an analyte in a sample and the use of the device for detecting an analyte in a sample, wherein a two-dimensional barcode of a plurality of reagent dots comprising bioreceptors is patterned or printed on the membrane, the plurality of reagent dots being arranged in form of a two-dimensional barcode visible after the completion of the test and in which a certain information associated with the analyte is embedded, and to the use of said device.

PHOTOPOLYMERISABLE NATURAL OIL-BASED COMPOSITIONS FOR 4D PRINTING OF MULTIFUNCTIONAL BIOMATERIALS

Resumen de: WO2026083418A1

The present invention provides a photopolymerisable composition for 4D printing, comprising an acrylated polyol (AOPO) derived from a natural oil, such as olive oil, and acrylic acid as a comonomer. The composition is used in a solvent-free digital light processing (DLR) method to fabricate high-resolution, multifunctional objects. The resulting 4D printed objects are biocompatible, hemocompatible, and cytocompatible. They exhibit excellent temperature- responsive shape memory properties activated near body temperature, inherent antimicrobial activity against both gram-negative and gram-positive bacteria, and tuneable mechanical properties suitable for soft tissue engineering. Furthermore, the composition can be loaded with therapeutic agents, such as progesterone, to form biodegradable objects capable of sustained, controlled drug release. These properties make the material ideal for medical implants, cardiovascular stents, and drug delivery devices.

FIXED DENTAL APPLIANCE FOR CONTROLLED DRUG DELIVERY

Resumen de: US20260108339A1

0000 A drug delivery device may include a component with a bonding location to be bonded to a surface of one or more teeth. A cavity may hold a formulation that includes a compound, and an orifice may release the compound outside the component.

DIGITAL SPIRAL TRACING AND FREE DRAWING TESTS

Resumen de: US20260108182A1

0000 Systems and methods are directed to screening a subject for motor and cognitive impairment. A method for screening motor and cognitive impairment comprises administering a spiral tracing assessment to a subject, and receiving a response thereto; assessing the subject's performance based on the response; collecting performance parameters based on the subject's performance on the spiral tracing assessment; providing the performance parameters and the response to a pretrained machine learning model; predicting, using the pretrained machine learning model, a likelihood of the patient having a cognitive impairment; determining a motor and cognitive impairment status of the patient based on the prediction; and outputting the motor and cognitive impairment status.

METHOD AND PROCESS FOR MAKING TATTOO STENCIL INK

Nº publicación: WO2026085208A1 23/04/2026

Solicitante:

TROY GROUP INC [US]

Resumen de: WO2026085208A1

An ink composition for a tattoo stencil and methods of making the same are disclosed herein. The ink composition comprises a plurality of cationic violet dyes in combination with a humectant, optionally along with surfactants and/or alcohol. It exhibits enhanced color vibrancy and color reproduction of the transferred tattoo design. The disclosed ink composition also exhibits excellent stability under thermal conditions and is suitable for long-term storage.