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LastUpdate Última actualización 21/06/2025 [08:47:00]
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Methods of administering chimeric antigen receptor immunotherapy

NºPublicación:  AU2025203054A1 22/05/2025
Solicitante: 
KITE PHARMA INC
Kite Pharma, Inc
AU_2025203054_A1

Resumen de: AU2025203054A1

The disclosure provides cells comprising CD19-directed chimeric antigen receptor (CAR) genetically modified autologous T cell immunotherapy for the treatment of, e.g., relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal large B-cell lymphoma, high grade B-cell lymphoma, and DLBCL arising from follicular lymphoma. Some aspects of the disclosure relate to methods of treatment and monitoring following infusion of T cell therapy provided herein.

METHODS AND COMPOSITIONS FOR TREATMENT OF LEUKEMIA

NºPublicación:  WO2025106552A1 22/05/2025
Solicitante: 
NKARTA INC [US]
NKARTA, INC
WO_2025106552_PA

Resumen de: WO2025106552A1

Several embodiments of the methods and compositions disclosed herein relate to immune cells that are engineered to express chimeric receptors and various dosing regimens for administering such cells. In several embodiments, the immune cells express a chimeric receptor that targets ligands of NKG2D. In several embodiments, the cancer is a leukemia, such as acute myeloid leukemia (AML).

CELLULAR THERAPIES FOR CANCER AND AUTO-IMMUNE DISORDERS USING FUNCTIONAL GENE VARIANTS IDENTIFIED BY BASE-EDITING SCREENING OF HUMAN T CELLS

NºPublicación:  WO2025106732A1 22/05/2025
Solicitante: 
UNIV COLUMBIA [US]
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
WO_2025106732_PA

Resumen de: WO2025106732A1

Single-nucleotide variants (SNVs) in key T cell genes can drive clinical pathologies and could be repurposed to improve cellular cancer immunotherapies. Here, we perform massively parallel base editing screens to generate thousands of variants at gene loci annotated with known or potential clinical significance. We discover a broad landscape of putative gain- (GOF) and loss-of-function (LOF) mutations, including in PIK3CD and its regulatory subunit PIK3R1, LCK, SOS, AKT1, and RHOA. Base editing of PIK3CD and PIK3R1 variants in T cells with an engineered T cell receptor specific against a melanoma epitope or in different generations of CD19 chimeric antigen receptor T (CAR-T) cells demonstrates that discovered GOF variants, but not LOF or silent mutation controls, enhanced signaling, cytokine production and lysis of cognate melanoma and leukemia cell models, respectively. Additionally, we show that generations of CD19 CAR-T cells engineered with PIK3CD GOF mutations demonstrate enhanced antigen-specific signaling, cytokine production, and leukemia cell killing, including when benchmarked against other recent strategies.

STAT3 DEGRADERS FOR USE IN TREATING LEUKEMIA

Nº publicación: WO2025106485A1 22/05/2025

Solicitante:

KYMERA THERAPEUTICS INC [US]
ALBERT EINSTEIN COLLEGE MEDICINE [US]
KYMERA THERAPEUTICS, INC,
ALBERT EINSTEIN COLLEGE OF MEDICINE

WO_2025106485_PA

Resumen de: WO2025106485A1

The present invention relates to STAT3 degraders and methods of use thereof for treating leukemia.

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