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265
resultados
Última actualización
27/04/2026 [08:33:00]
Resultados 100 a 125 de 265
Resumen de: US20260083826A1
The present invention aims to provide a novel agent for treating Alzheimer's disease, a method for treating Alzheimer's disease, a method for screening for a candidate substance for a therapeutic drug for Alzheimer's disease, and the like. The present invention is a prophylactic and/or therapeutic agent for Alzheimer's disease comprising a peptide corresponding to dynamin 1. The peptide preferably corresponds to dynamin 1-pleckstrin-homology domain or dynamin 1-proline rich domain. In addition, the peptide is preferably encapsulated in nano-particles or linked to a peptide sequence that improve delivery of the peptide into the brain.
Resumen de: WO2026064356A2
Mismatch anchoring compounds (MACs) are disclosed that recognize and bind to specific base-pair mismatches (mmBP) present within single stranded or double stranded DNA, RNA, and oligonucleotide sequences, and enable the ex vivo identification of DNA/RNA point mutations (DNAPM/RNAPM), including disease-associated, rare, and low abundance DNAPM/RNAPM, and the isolation and elimination of mmBP-positive cells. The use of MACs in vitro and in vivo (a) blocks mmBP-positive DNA replication and gene transcription/expression, (b) inhibits mmBP-positive cell proliferation, (c) reverses, prevents, and/or treats mmBP-rnediated disease, aging, and age-related disorders, (d) blocks mmBP-positive RNA and/or RNA-DNA duplex translation and inhibits the production of abnormal disease-causing proteins, (e) silence mmBP-positive genes, and (f) blocks intracellular pathogen replication. MAC-conjugates and their uses are disclosed, including MACs radiolabeled with SPECT/PET/particle-emitting isotopes for radioimaging and/or radiotherapy of mmBP-positive diseases.
Resumen de: DE102024127976A1
Eine mikrofluidische Vorrichtung (12) zum Probenauftrag einer Körperflüssigkeit auf ein konditioniertes Sensorelement für eine Detektion von molekularen Biomarkern in der Körperflüssigkeit und/oder zum Konditionieren des Sensorelements (14) mittels eines Konditionierungsfluids umfasst zumindest eine Interaktionskammer (40), die abschnittsweise durch ein Sensorelement (14) geschlossen ist. Eine Pneumatikeinheit (70) ist mit der zumindest einen ersten Aufnahme (46) verbunden und dazu eingerichtet, diese mit Überdruck zu beaufschlagen und die Körperflüssigkeit oder das Konditionierungsfluid durch die zumindest eine Interaktionskammer (40) entlang der behandelten Oberfläche (16) einmalig und unidirektional und anschließend in den zumindest einen Entsorgungsbehälter (52) zu pumpen, so dass bei Körperflüssigkeit Biomarker an der Oberfläche (16) haften oder bei Konditionierungsfluid die Oberfläche konditioniert ist. Ferner werden eine Biomarkerdetektionsvorrichtung (18) und eine Verfahren zum Probenauftrag einer Körperflüssigkeit auf ein konditioniertes Sensorelement (14) für eine Biomarkerdetektion und/oder zum Konditionieren eines Sensorelements (14) für eine Biomarkerdetektion vorgeschlagen.
Resumen de: WO2026064744A1
The subject invention provides materials and methods for treating diseases affecting the central nervous system (CNS) and/or other viral reservoir organs utilizing nanoscopic diamond particles, i.e., nanodiamonds (ND), loaded with drug molecules and microglial targeting moiety.
Resumen de: US20260086100A1
0000 Provided are methods of determining risk for chronic stress and stroke. More specifically, provided is an early prognostic index that can be used to predict chronic stress and stroke risk. There is provided a method of evaluating the risk of developing chronic stress and stroke, the method including obtaining a biological sample from an individual; measuring the levels of a set of biomarkers in the biological sample obtained from the individual; measuring the levels of a set of clinical markers of the individual; using a computer to programmatically generate an index based on the levels of biomarker in the biological sample obtained from the individual in combination with levels of the individual's clinical marker; and using the index to identify a likelihood that the individual will experience chronic stress and stroke.
Resumen de: WO2026064655A1
Provided are nucleic acids encoding voltage indicator polypeptides. In some instances, the voltage indicator polypeptide comprises a voltage-sensing domain (VSD) comprising four transmembrane segments, and a circularly permuted fluorescent protein inserted into an extracellular loop between the third transmembrane segment (S3) and the fourth transmembrane segment (S4) of the VSD. The voltage indicator polypeptide may comprise one or more amino acid substitutions and/or deletions, non-limiting examples of which include one or more substitutions at I412, F413 and/or Q414, wherein numbering of positions is according to SEQ ID NO: 1. Cells comprising the nucleic acids are also provided. In some embodiments, the cells are neurons that express the voltage indicator polypeptide on the plasma membrane of the neuron in a pan-membrane or targeted manner. Methods of recording the electrical activity of neurons are also provided, as are methods of assessing an effect of an agent on the electrical activity of neurons.
Resumen de: US20260086093A1
0000 The present invention relates to methods for the determination of the residence time between at least one Target and at least one Ligand, optionally in their native biological context, using limited proteolysis e.g., combined with selected reaction monitoring, parallel reaction monitoring, data-independent acquisition (DIA), including Sequential Windowed Acquisition of All Theoretical Fragment Ion Mass Spectra (SWATH) methods and the like.
Resumen de: WO2026064441A1
The disclosure is related to methods of treating a subject with Alzheimer's Disease (AD) using anti-amyloid beta (Aβ) therapy. The patient may be treated based on the measurement and analysis of biomarker levels, such as plasma Aβ42/40 ratio, pTau181 and pTau217. The disclosure includes a systematic approach called CP Convert for converting biomarker measurements across different analytical platforms, enabling comparison of pTau217 data from LC-MS/MS, SIMOA, and chemiluminescent enzyme immunoassay platforms. Methods demonstrate that pTau217 has superior diagnostic accuracy compared to Aβ42/40 ratio and pTau181 for detecting brain amyloid positivity. Implementation of pTau217 prescreening can significantly reduce Aβ-PET testing, decreasing patient burden and clinical trial costs. The CP Convert methodology can be validated using independent cohorts, demonstrating robust cross-platform conversion for research applications.
Resumen de: WO2026063647A1
The present invention relates to an antibody specifically binding to TDP-43 and use thereof. When the antibody of the present invention is used, the level of TDP-43, particularly TDP-43 aggregates, can be effectively detected. Therefore, the present invention can be a powerful tool for distinguishing TDP-43 proteinopathy from other clinically similar neurodegenerative diseases and diagnosing TDP-43 proteinopathy, serving as a biomarker for TDP-43 proteinopathy, including FTD, ALS, LATE, and the like.
Resumen de: US20260086063A1
0000 Circulatory failure generates hypoxia and leads to accumulation of reductive species in tissue and circulatory failure monitoring tools are needed but rare. Cardiopulmonary bypass (CPB) is known to promote brief circulatory failure during its initiation. In the present study, the Inventors demonstrate a correlation between whole blood redox potential and circulatory failure during (CPB). They made a prospective study with 17 patients eligible for cardiac surgery with cardiopulmonary bypass. They demonstrated a frank reduction of the whole blood redox potential during circulatory failure during the initiation of CPB. They also demonstrated that they were able to classify patients in 3 groups, one of them presenting an unfavorable post-operative outcome. Accordingly, the present invention relates to a method of diagnosing acute circulatory failure in a patient comprising determining the level of redox potential in a sample obtained from said patient, wherein the level of redox potential indicates whether the patient suffers or not from an acute circulatory failure.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: CN121152975A
The present invention relates to the use of biomarkers for measuring the efficacy or effectiveness of a treatment for neurodegenerative diseases, in particular Alzheimer's disease.
Resumen de: CN121721265A
本公开涉及生物医学传感领域，具体涉及一种基于人工智能算法的单分子计数免疫分析系统，用于解决现有技术中在痕量蛋白检测和定量分析方面的灵敏度不足、信噪比不足、定量精度受限和数据处理效率低等问题。本公开技术方案通过明场和暗场双模式成像技术，针对基于利用离散载体及微纳荧光材料进行免疫分析的体系，结合图像处理算法和深度学习模型，提供高灵敏度、高精度、高信噪比的单分子免疫物质检测。
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: CN121721289A
本发明属于分子生物学领域，具体地，涉及一种空间蛋白质组学分析方法，更具体地，涉及一种同时进行细胞类型成像和原位蛋白质组学分析的空间蛋白质组学分析方法。使用本发明的方法能够在同一组织切片上同时进行细胞类型成像和原位蛋白质组学分析，减小潜在的偏差，使得分析结果更为准确。
Resumen de: CN121717902A
本公开提供了一种抗人磷酸化tau217的兔源单克隆抗体及其制备方法和应用，属于生物检测、生物工程技术领域。抗人磷酸化tau217的兔源单克隆抗体包括轻链可变区和重链可变区，单克隆抗体包括HZK33‑B0010、HZK33‑B0011和HZK33‑B0029。本公开开发了识别p‑tau217的三种兔单克隆抗体，其不会与非磷酸化的tau蛋白或其他位点的磷酸化tau蛋白发生交叉反应，能够高度特异性地结合p‑tau217，并以此开发出更具特异性的相关体液标记物检测试剂盒。
Resumen de: CN121717907A
本公开涉及生物医药领域，提供了一种人BCMA抗体及其应用。本公开提供的抗BCMA单克隆抗体1F5与BCMA抗原具有较强的亲和能力，Kd值为0.752×10‑9 M；为鼠源IgG1亚型，轻链为κ链；能够高亲和力结合BCMA阳性细胞系H 929和RPMI 8226，与多发性骨髓瘤病人来源的CD138阳性骨髓单个核细胞也能高亲和力结合。鉴于这些特性，单克隆抗体1F5既可用于检测表达人BCMA的细胞，也能够单独或与其它方法联合应用在靶向人BCMA的肿瘤免疫治疗中，具有诊断和治疗价值。
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: WO2024263939A1
The present disclosure relates method of identifying a compound targeting a first protein and a second protein, wherein the first protein and/or the second protein are associated with a disease or disorder.
Resumen de: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Resumen de: US20260079153A1
0000 Methods for generating mature neurons differentiated from pluripotent stem cells, such as to facilitate the study of late-onset neurodegenerative disease, are disclosed. The methods include overexpressing the splicing factor muscleblind like splicing regulator 2 (Mbnl2) in cortical neurons. In some aspects, the method further comprises overexpressing RNA binding fox-1 homolog 1 (Rbfox1) and/or reducing expression of polypyrimidine tract binding proteins PTBP1/2. The methods also include accelerated derivation of mature neuron and generation of a tau pathology model. Also disclosed are constructs and compositions for accelerated derivation of mature neuron and/or generation of a tau pathology model.
Nº publicación: JP2026509486A 19/03/2026
Solicitante:
アルツパス，インコーポレイテッド
Resumen de: US20260008840A1
Provided herein are compositions and methods relating to improved assays for establishing a condition of a neurodegenerative disease and providing treatment. Further provided herein are compositions and methods comprising improved antibodies for assays including immunoassays used for diagnosing Alzheimer's disease and providing treatment.
BOPI
Sede Electrónica
