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160
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Última actualización
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Resultados 150 a 160 de 160
Resumen de: CN120398997A
The invention discloses a compound with hypoxia-inducible factor-1 alpha (HIF-1 alpha) protein degradation activity as well as a synthesis method and application thereof. The compound degrades HIF-1alpha protein through a ubiquitin-proteasome pathway, and is suitable for treating diseases such as cancers (such as pancreatic cancer and cervical cancer), encephaledema, atherosclerosis, rheumatoid arthritis, psoriasis, Alzheimer's disease and glaucoma related to overexpression of HIF-1alpha. Experiments show that the compound can significantly degrade HIF-1alpha protein, the synthesis method is simple and convenient, raw materials are easy to obtain, and the compound has wide drug development prospects.
Resumen de: CN120392918A
The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses preparation and application of a sixteen-component medicine-food homologous prescription for treating Alzheimer's disease and depression through intelligence development and depression, and the preparation method comprises the following steps: S1, weighing the medicinal materials according to the prescription dosage, cleaning, selecting, drying and crushing to 50-100 meshes; s2, adding water into the medicinal materials, decocting for 1-3 times, decocting for 0.5-2 hours each time, combining filtrates at 60 DEG C, and concentrating until the relative density is 1.10-1.30, wherein the amount of added water is 5-15 times of the weight of the medicinal materials; s3, treating the concentrated solution by an alcohol precipitation method, standing, and recovering ethanol to obtain an extract; s4, mixing the extract with auxiliary materials to prepare one of granules, capsules or tablets; according to the traditional Chinese medicine composition disclosed by the invention, through a multi-target synergistic effect, cognitive dysfunction and mood disorder of patients with senile dementia and depression are remarkably improved. The tonifying medicinal materials such as the astragalus membranaceus and the rhizoma polygonati in the formula can enhance cerebral blood flow, inhibit beta amyloid protein deposition and tau protein phosphorylation and delay neurodegenerative
Resumen de: CN120393055A
The invention discloses an application of NeuroD1 (NeuroD1) in repairing Alzheimer's disease (Alzheimer's disease). The invention also discloses an application of the carrier for coding NeuroD1 in any one of the following aspects: preventing neuron damage and apoptosis; hippocampus atrophy is inhibited; the neuroinflammation is relieved; repairing blood vessel/blood brain barrier injury; the AD biomarker level of the cerebrospinal fluid is recovered to be normal; the removal of pathological toxic proteins in brain tissues is promoted; glucose metabolism is improved; the space working memory ability is enhanced; and regenerating neurons.
Resumen de: CN120392785A
The invention discloses novel application of notoginsenoside Rg1, namely application of the notoginsenoside Rg1 in preparation of a cathepsin D (CTSD) inhibitor, the notoginsenoside Rg1 can inhibit CTSD enzyme activity so as to recover lysosome structure and function, relieve endoplasmic reticulum stress reaction and relieve alpha-syn aggregation and dopaminergic neuron apoptosis, has a remarkable protection effect on a Parkinson's disease model, and can be used for preparing a novel anti-inflammatory drug. The invention provides a new thought and a potential drug basis for targeted intervention of Parkinson's disease. The invention discloses a new mechanism that Rg1 plays a role in neuroprotection through a CTSD-lysosome-endoplasmic reticulum stress pathway.
Resumen de: MX2025007590A
Provided herein a method of treating Juvenile Huntington disease in a subject in need thereof comprising orally administering a pharmaceutical composition comprising pridopidine and/or its analog or a pharmaceutically acceptable salt thereof.
Resumen de: TW202434616A
Compounds, compositions, uses, and methods for increasing cell viability of a dopaminergic neuron, or for preventing or treating dopaminergic neuronal death, are provided herein. In certain examples, methods for reducing symptoms and/or for preventing or treating Parkinson's disease in a subject in need thereof are provided which may include a step of treatment with a GDP-bound form of Rab1a (Rab1a<SP>GDP</SP>), one or more expressible nucleic acids encoding Rab1a<SP>GDP</SP>, or a combination thereof.
Resumen de: MX2025005198A
4-Aminopyrrolo2,I-f1,2,4triazine compounds of formula I for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of 4- aminopyrrolo2,1-fl,2,4triazine compounds or analogs thereof, in the treatment of disorders characterized by overexpression of DYRK1A (e.g., cancer, Down syndrome, Alzheimer's disease, diabetes, and osteoarthritis).
Resumen de: MX2025007590A
Provided herein a method of treating Juvenile Huntington disease in a subject in need thereof comprising orally administering a pharmaceutical composition comprising pridopidine and/or its analog or a pharmaceutically acceptable salt thereof.
Resumen de: MX2025008034A
The present disclosure provides anti-amyloid β (Aβ) antibodies and antibody fragments that preferentially bind soluble amyloid Aβ protofibril/oligomer and trigger ADPC in microglial cells, anti-amyloid β (Aβ) antibodies and antibody fragments that reduce soluble amyloid Aβ protofibril/oligomer levels and insoluble amyloid Aβ plaque in brain tissue, and the use of anti-Aβ protofibril/oligomer antibodies and antibody fragments in therapy, prophylaxis, diagnosis, screening, and monitoring of conditions associated with Aβ protein aggregation, in particular Alzheimer's disease (AD).
Nº publicación: MX2025008267A 01/08/2025
Solicitante:
VOYAGER THERAPEUTICS INC [US]
VOYAGER THERAPEUTICS, INC
Resumen de: MX2025008267A
The disclosure relates to compositions and methods for altering, <i>e.g.</i>, enhancing, the expression of GCase proteins, whether <i>in vitro</i> and/or <i>in vivo</i>. Such compositions include delivery of an adeno-associated viral (AAV) particle. The compositions and methods of the present disclosure are useful in the treatment of subjects diagnosed with, or suspected of having Parkinson's Disease (PD), Gaucher Disease (GD), Dementia with Lewy Bodies (DLB), or related condition resulting from a deficiency in the quantity and/or function of GBA1 gene product or associated with decreased expression or protein levels of GCase protein.
BOPI
Sede Electrónica
