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197
resultados
Última actualización
02/08/2026 [07:20:00]
Resumen de: CN122081529A
The invention discloses a composition for simultaneously detecting staphylococcus aureus and salmonella based on CRISPR-Cas12a/Cas12b, a method and application, and belongs to the technical field of food safety detection. Based on the characteristics of RPA isothermal amplification and preference of different Cas12 enzyme cleavage positions, a dual RPA-CRISPR-Cas12a/Cas12b detection method for staphylococcus aureus and salmonella is established through primer screening and optimization of parameters such as crRNA, reaction time and temperature, and the problem that it is difficult to detect multiple DNA targets of a Cas12 system at the same time is effectively solved. The method is good in specificity, high in sensitivity and simple in result interpretation, the detection limits of pure cultures and artificially polluted samples can reach the order of magnitude of 100 CFU/mL, detection can be completed within 1 h, and a new technical path is provided for rapid screening of food-borne pathogenic bacteria.
Resumen de: CN122071681A
The invention discloses a recombinant engineering bacterium, a preparation method thereof and application of the recombinant engineering bacterium in preparation of antithrombotic drugs, and belongs to the technical field of biological medicines. The recombinant engineering bacterium is prepared by taking salmonella typhimurium with relA and spoT gene mutations as a carrier and introducing a recombinant plasmid containing a thrombolytic enzyme coding gene into the carrier. The invention provides a recombinant engineering bacterium with biological safety, the recombinant engineering bacterium has high thrombus targeting property under a dynamic blood flow condition, various thrombus models can be specifically targeted, and the concentration of the recombinant engineering bacterium in thrombus tissues can reach more than ten thousand times of the concentration of normal tissues such as spleen, liver and the like through bacterium proliferation. Through mediated thrombus targeted therapy, thrombus can be effectively dissolved, and revascularization is achieved. The invention provides a more effective and safer treatment strategy for diseases caused by thrombus, such as myocardial infarction, cerebral apoplexy, pulmonary embolism and the like.
Resumen de: US20260140114A1
The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.
Resumen de: US20260139012A1
A method for increasing the presentation of ETEC CS6 antigen on a cell surface, comprising the step of contacting cells expressing said antigen with an aqueous solution comprising 0.6-2.2 percent phenol by weight, such that the presentation of said antigen is increased by at least 100%. A method for the manufacture of a killed whole cell vaccine for immunization against CS6-expressing ETEC. Cells and vaccines obtainable by the above methods.
Resumen de: AU2026203336A1
Outer membrane vesicles from bacteria of the Burkholderia pseudomallei complex can be used as adjuvants in compositions and methods to potentiate the immune response to immunogens. ay a y
Resumen de: US20260137738A1
The present invention relates to a novel bacteriophage OPT-SALO1 with specific killing ability for Salmonella enterica, an antibiotic composition comprising the bacteriophage, a composition for adding to a feed, a feed, a disinfectant or a cleaning agent, and a method for preventing or treating infectious diseases caused by Salmonella enterica comprising a step of administering the bacteriophage to a subject.
Resumen de: AU2026203393A1
DETOXIFIED LIPOPOLYSACCHARIDES (LPS), NATURALLY NON-TOXIC LPS, AND USES THEREOF The invention relates to an enriched population of modified lipopolysaccharide (LPS) molecular species being: - devoid of phosphate group at position C1 of the reducing end of their lipid A domain; and - substituted at position C6’ of the non-reducing end of their lipid A domain by a 10 hydrophilic moiety, with the proviso that said hydrophilic moiety is not a hydroxyl group. It also relates to compositions comprising the enriched population of modified LPS; and uses of naturally-occurring LPS molecular species and/or enriched population of modified LPS molecular species for treating and/or preventing cancer, inflammatory 15 diseases or infectious diseases, and for stimulating an immune response or vaccinating a subject. - 10 - ay a y - - 1
Resumen de: US20260137765A1
A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.
Resumen de: CN122056327A
The invention discloses application of lactobacillus plantarum Y40. The lactobacillus plantarum Y40 is used for improving the growth performance of meat ducks, improving the meat quality, enhancing the oxidation resistance and increasing the diversity of intestinal flora and the abundance of species. The duck meat color can be improved under the condition of salmonella typhimurium infection, the colonization level of pathogenic bacteria in immune organs of meat ducks is remarkably reduced, intestinal flora balance is remodeled, and the resistance of a host to salmonella typhimurium invasion is enhanced. The invention provides a new microbial resource for growth promotion, disease prevention and antibacterial application in livestock and poultry breeding, and has a good industrialization prospect.
Resumen de: CN122060644A
The invention relates to the technical field of microbial fermentation, and discloses bacillus subtilis, application of the bacillus subtilis in fermented soybean meal and a preparation method of the fermented soybean meal. The bacillus subtilis screened by the invention has strong anti-nutritional factor resistance (such as glycinin, beta-conglycinin, raffinose and stachyose), has a good growth effect in the soybean meal raw material, and is used for fermenting the soybean meal raw material; the content of anti-nutritional factors (such as glycinin, beta-conglycinin, raffinose and stachyose) in the soybean meal raw material can be obviously reduced, and meanwhile, the content of lipopeptide substances (such as surfactin and bacitracin D) in the fermented soybean meal product can be obviously improved; the prepared fermented soybean meal product has a good antibacterial effect on three common intestinal pathogens (escherichia coli, salmonella and staphylococcus) in animal bodies.
Resumen de: CN122063016A
The invention discloses an oil immersion lens microscopic imaging multi-target simultaneous detection platform based on machine vision and application, and belongs to the field of biochemical analysis. The aptamer is adopted as a recognition element and matched with the corresponding complementary DNA chain and the combined DNA chain, the aptamer and the DNA chain can be replaced according to a target object, operation is easy and convenient, good applicability and universality are achieved, the size of an observation area is reduced to the dry size of a liquid drop area from the size of a conventional cover glass, visual field loss is greatly reduced, and the detection accuracy is improved. The visual imaging of a single microsphere can be realized, the signal sensing is direct and efficient, and the detection sensitivity is high; the multi-detection capability of the color and particle size combination of the microspheres is strong; the used recognition elements are all DNA sequences, so that the use cost of the recognition elements such as antibodies can be greatly reduced.
Resumen de: CN122060881A
The invention belongs to the technical field of microbiological detection and molecular diagnosis, and discloses a primer group, a kit and a detection method for detecting salmonella enteritidis, the kit comprises an immunocapture component, an isothermal amplification component, a CRISPR/Cas12a detection component and auxiliary components; the isothermal amplification component is any one of an RPA (recombinase polymerase amplification) component or an LAMP (loop-mediated isothermal amplification) component, the RPA component comprises a specific primer group targeting 86th to 212th nucleotides in a salmonella enteritidis hilA gene coding region, and the LAMP component comprises a specific primer group targeting 58th to 250th nucleotides in the salmonella enteritidis hilA gene coding region. The primer group, the kit and the detection method for detecting the salmonella enteritidis successfully integrate three key technologies of RAP and LAMP rapid isothermal amplification, CRISPR/Cas12a high-specificity recognition and trans-cleavage and immunomagnetic bead targeted enrichment, and creatively provide the primer group, the kit and the detection method for detecting the salmonella enteritidis.
Resumen de: CN122056860A
The invention relates to the technical field of biological medicine, in particular to application of flufenamic acid in preparation of a polymyxin E antibacterial synergist. The invention discloses an application of flufenamic acid in preparation of a polymyxin E antibacterial synergist, the flufenamic acid has no obvious antibacterial effect on salmonella when being independently used, but the flufenamic acid and polymyxin E can enhance the antibacterial activity of the polymyxin E on the salmonella and reduce the use dosage of the polymyxin E when being jointly used in and out of an animal body, so that the antibacterial effect of the polymyxin E on the salmonella can be enhanced. The antibacterial activity of the polymyxin E on salmonella is enhanced, and the drug resistance of the polymyxin E is inhibited. Flurfenamic acid is approved to be used for other purposes as FDA, and when the flurfenamic acid is combined with polymyxin E, the flurfenamic acid has the characteristic of high safety, and meanwhile, the generation of the drug resistance of the polymyxin E drugs can be effectively avoided. The invention provides a basis for mining a new antibacterial prevention and control strategy for the polymyxin E drug-resistant bacteria.
Resumen de: WO2026102349A1
Interleukin-23 receptor (IL23R) VHH antibodies are disclosed, as well as methods of making and using the same, e.g., for treatment of IL23-mediated diseases and disorders, including, e.g., gastrointestinal-related (Gl-related) diseases (e.g., inflammatory bowel disease (IBD) (e.g., ulcerative colitis (UC) or Crohn's disease (CD)), a colon cancer, a small intestine cancer, a gastric cancer, an irritable bowel syndrome, a gastrointestinal ulcer, a gut-associated infection (e.g., a Salmonella infection or a Clostridium difficile infection), celiac disease, or pathogenic inflammation).
Resumen de: CN122038223A
The invention provides clostridium butyricum pandaZhang, a microbial agent, a bacteriostatic agent and application of the clostridium butyricum pandaZhang, and belongs to the technical field of microorganisms. The preservation number of the clostridium butyricum pandaZhang is CCTCC (China Center for Type Culture Collection) NO: M 20253041. The clostridium butyricum pandaZhang is strong in antibacterial ability and wide in antibacterial spectrum, can generate antibacterial active substances such as lanheheptide through metabolism, and has a remarkable inhibition effect on various pathogenic bacteria such as escherichia coli, staphylococcus aureus, klebsiella pneumoniae, salmonella and proteus mirabilis. The strain has outstanding short-chain fatty acid production capacity, and can efficiently produce key metabolites such as propionic acid and butyric acid. When the strain is applied to breeding of weaned piglets, the growth performance of the piglets can be remarkably improved, the diarrhea rate of the weaned piglets is reduced, the intestinal health of the piglets is improved, and healthy and efficient breeding of the piglets under the antibiotic-free condition is achieved.
Resumen de: CN122031718A
The invention relates to the technical field of nano material preparation and biological medicine, in particular to a combined medicine of attenuated salmonella loaded barium titanate piezoelectric nano particles and application. The combined medicine provided by the invention is barium titanate piezoelectric nano-particles which are modified by a silane coupling agent and have the characteristics of good surface charges and the like, and the barium titanate piezoelectric nano-particles are combined on the surface of attenuated salmonella through electrostatic interaction. The invention further provides a preparation method of the combined medicine. The preparation method comprises the following steps: step 1, preparing the barium titanate piezoelectric nano-particles with good surface charge and other characteristics; and step 2, preparing the attenuated salmonella loaded barium titanate piezoelectric nano-particle combined medicine. The invention further provides application of the combined medicine in the anti-tumor aspect. The combined medicine disclosed by the invention has good anti-tumor performance and excellent biological safety, and a new thought is provided for bacterium-nanoparticle combined treatment.
Resumen de: CN122038605A
The invention relates to a primer probe group, a multiplex fluorescent quantitative PCR method and a kit for simultaneously detecting six pathogenic bacteria, and belongs to the technical field of molecular biology, the primer probe group comprises primer sequences and probe sequences shown in SEQ ID No.1-18 in a table 1; the 5'end of each probe sequence is modified with a reporter group, and the 3 'end of each probe sequence is modified with a quenching group; the reporter group is Cy5, FAM and VIC, and the quenching group is Eclipse. The invention provides a method for simultaneously detecting six pathogenic bacteria including vibrio parahaemolyticus, salmonella, staphylococcus aureus, escherichia coli O157: H7, listeria monocytogenes and shigella in the same reaction system by combining a multiple real-time fluorescent quantitative PCR (Polymerase Chain Reaction) technology. The multiplex real-time fluorescent quantitative PCR kit provided by the invention is used for detecting the six pathogenic bacteria, can improve the detection sensitivity and specificity, greatly improves the detection efficiency, and overcomes the defects of complex steps, long detection period and incapability of adapting to large-scale rapid detection in the conventional detection method.
Resumen de: CN122038409A
The invention discloses a biosensor detection reagent for detecting salmonella typhimurium and a preparation method, and belongs to the technical field of biomedicine. According to the invention, a DNA sequence of an amino-modified nucleic acid aptamer for detecting salmonella typhimurium is screened out and is shown as SEQ ID No: 1. Based on the nucleic acid aptamer, amino modified aptamer-fluorescent nano-enzyme serving as an energy donor and sulfydryl modified aptamer-gold nanoparticles serving as an energy receptor are mixed according to the volume ratio of 1: 1, and the biosensor detection reagent is prepared. The linear detection range of the biosensor detection reagent on salmonella typhimurium is 101-107 CFU/mL, the linear correlation coefficient R2 is equal to 0.9981, and the detection limit is as low as 1.527 CFU/mL. The biosensor detection reagent disclosed by the invention still keeps good selectivity and stability in a complex environment with high protein, high fat and high salt, and is suitable for rapid field detection in the fields of food safety and medical diagnosis.
Resumen de: WO2026098490A1
Disclosed in the present application is the use of Salmonella typhimurium-derived glutamate dehydrogenase and related biomaterials thereof in amino acid synthesis. Provided in the present application is the use of Salmonella typhimurium-derived glutamate dehydrogenase for improving the L-amino acid yield of a microorganism. In the present application, an optimized coding gene of the Salmonella typhimurium-derived glutamate dehydrogenase is further obtained by means of codon optimization, and the introduction of the optimized coding gene into a recipient microorganism can significantly improve the L-amino acid yield of the recipient microorganism.
Resumen de: US20260131039A1
This disclosure relates to a method for sanitizing a space. The method includes applying a composition containing triethylene glycol into a space containing a pathogen (e.g., a Staphylococcus, a Pseudomonas, a Listeria, Salmonella, Klebsiella, a mycobacterium, a mold, or a spore) in an amount effective to inactivate the pathogen.
Resumen de: US20260132409A1
The present disclosure provides fusion proteins comprises fusion proteins comprising the signal sequence of PduB or PduM and a heterologous protein, as well as constructs for expressing the fusion proteins, and methods of their use. The fusion proteins are designed to deliver the heterologous proteins to bacterial microcompartments and modify the 1,2-propanediol metabolic pathway.
Resumen de: WO2018208840A1
Provided are novel methods for screening and testing for pathogens in food, water, and bodily fluids using methods that are faster to complete than conventional methods of culturing and plating that require lengthy times in properly equipped labs. The invention utilizes specific, rapid and sensitive optical detection to capture small concentrations of the target bacteria and render them amenable for detection with various specific synthesis binding agents approaches. The technique merges capture and detection steps with quantification unit suitable to provide results in a relatively shorter time current detection methods.
Resumen de: CN122012317A
The invention discloses a cat lactic acid bacteria strain and application thereof, and belongs to the field of microbial preparations. According to the invention, a cat-source probiotic strain, namely pediococcus acidilactici G91, with excellent characters is screened from healthy kittens. The strain not only is subjected to acid-resistant and cholate-resistant severe digestive tract environment simulation screening, but also shows excellent self-aggregation capability, surface hydrophobicity, cell adhesion capability, antibacterial capability and other core probiotic characteristics. Further biological identification and hemolytic property and drug sensitivity determination prove that the strain is safe pediococcus acidilactici which is non-hemolytic and sensitive to antibiotics, G91 can promote growth and development of seedlings, improve intestinal barriers and functions, regulate intestinal flora and immune systems and effectively resist salmonella constant value and infection, and the strain has excellent probiotic performance and can be used for preparing the feed additive. The strain is an ideal strain resource for developing a micro-ecological preparation for cats, and provides a safe and efficient novel micro-ecological product and a technical scheme for healthy breeding and disease prevention of pet cats.
Resumen de: CN122012355A
The invention relates to the technical field of microorganisms, in particular to a lactobacillus plantarum strain LT304 and application thereof.The lactobacillus plantarum strain LT304 is separated from an acid material, and a fermentation product of the strain has an antibacterial effect on one or more of salmonella enteritidis, escherichia coli and listeria monocytogenes; after fermentation of the strain LT304, compared with fermentation of other same strains, enzyme activities of PAL, POD, PPO, APX and CAT in pickled Chinese cabbages are reduced, enzyme activity of LOX is increased, and the pickled Chinese cabbages are brightest; the lactobacillus plantarum LT304 strain has an obvious anti-browning effect on the leaf mustard pickled Chinese cabbages, and after histidine and/or proline are/is added for fermentation, the brightness can be further improved, and the color of the pickled Chinese cabbages is better, so that the LT304 strain can be used for preparing the pickled Chinese cabbages with better color, can effectively prevent browning, provides a new thought for follow-up development of anti-browning agents, and has wide application prospects. The fermentation liquor has the value of research and development of antibacterial peptides.
Nº publicación: CN122012356A 12/05/2026
Solicitante:
HUNAN AGRICULTURAL UNIV
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Resumen de: CN122012356A
The invention discloses a lactobacillus amyloliquefaciens and probiotic microbial inoculum and application of the lactobacillus amyloliquefaciens and probiotic microbial inoculum. The lactobacillus amyloporus is named as lactobacillus amyloporus YI39, and the preservation number of the lactobacillus amyloporus YI39 in the China Center for Type Culture Collection is CCTCC (China Center for Type Culture Collection) NO: M2026104; the nucleotide sequence of 16SrDNA (deoxyribonucleic acid) of the gene is SEQ ID NO. 1. The lactobacillus amyloliquefaciens YI39 provided by the invention is separated from ileum contents of 28-day-old healthy and rapid yellow-feathered broilers, has strong probiotic characteristics, and has relatively good capabilities of inhibiting growth of salmonella pullorum, avian pathogenic escherichia coli, A-type clostridium perfringens and staphylococcus aureus; the body of the broiler chicken can be effectively regulated and controlled, so that the chicken necrotic enteritis caused by clostridium perfringens infection is prevented.
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