Resumen de: US2025338857A1
An RNA interference method for controlling insect pests by inhibiting translation of messenger RNA (mRNA) of target genes in the insect's cholinergic system. The method includes preparing double-stranded RNA (dsRNA) or single-stranded antisense oligonucleotides specific to target mRNAs encoding nicotinic acetylcholine receptor subunits or auxiliary proteins, and administering an effective amount to induce mortality or increase sensitivity to insecticides. The target mRNAs include neuronal α and β subunits of nicotinic receptors and auxiliary proteins such as RIC-3, Lynx, NACHO, and UNC-50. Administration may be topical, oral, or through transgenic plants expressing the interfering RNA. The method is particularly effective against agricultural pests like Acyrthosiphon pisum and can restore sensitivity in insecticide-resistant insects. Compositions including the interfering RNA with transfection agents or solvents are provided, along with transgenic plants expressing the interfering RNA.
Resumen de: WO2025230089A1
The present invention relates to a strain for controlling tomato bacterial wilt and promoting tomato growth, and to a method for controlling tomato bacterial wilt and a method for promoting tomato growth using same. A microbial agent containing the motile mutant strain or a metabolite of production change due to deletion of a flagellin protein gene, according to the present invention, can control tomato bacterial wilt at a level comparable to registered levels of synthetic pesticides by an eco-friendly and low-input method. In addition, a microbial formulation comprising a non-pathogenic Ralstonia solanacearum Gj707 strain or RSp1180 protein, which is the adhesin protein represented by SEQ ID NO: 2, according to the present invention, can control tomato bacterial wilt at a level comparable to registered levels of synthetic pesticides. Furthermore, the tomato root adhesion protein of the bacterial wilt pathogen can be utilized for developing agents with site-specific action against bacterial wilt, thereby enabling efficient and health-friendly management of bacterial wilt, for which no dedicated agents are currently registered. Unlike general synthetic pesticides, such formulations also promote tomato growth, and thus are expected to increase the production and income of tomatoes in farmhouses.
Resumen de: WO2025227572A1
Provided are a Cronobacter phage, a liquid formulation thereof, and use thereof in the prevention and control of Cronobacter sakazakii. The provided phage is Cronobacter phage vB_CsaM_2375H2, which is a novel phage belonging to Pseudotevenvirus and has an accession number of CCTCC NO: M 2024570. The phage vB_CsaM_2375H2 has good stability at pH 3-11 and a temperature of 25-70 °C and does not carry any virulence or antibiotic resistance gene, meeting the safety requirements in actual applications. The phage vB_CsaM_2375H2 specifically lyses Cronobacter sakazakii and can remove the biofilm of Cronobacter sakazakii, with a biofilm removal rate of up to 62.55%.
Nº publicación: WO2025227210A1 06/11/2025
Solicitante:
UNIV FEDERAL DO ESTADO DO RIO DE JANEIRO [BR]
DIAS DE OLIVEIRA ANA CLAUDIA [BR]
UNIVERSIDADE FEDERAL DO ESTADO DO RIO DE JANEIRO,
DIAS DE OLIVEIRA, Ana Claudia
Resumen de: WO2025227210A1
The present invention relates to sustainable compositions that promote plant growth. More specifically, the invention relates to compositions containing endophytic microorganisms from plant tissues and media for growth and maintenance. The invention also relates to the endophytic microorganism and use of same for treating plants.